UK Corporate Governance Code Essay Example | Topics and Well Written Essays - 1750 words

UK Corporate Governance Code - Essay Example As a result, the board of directors of a company, which is the ultimate decision making authority of a company, has been forced to become more accountable to the shareholders. However, the present Combined Code on Corporate Governance has been more of a reaction to worldwide business scandals rather than being a pro-active measure that ensures business legitimacy (Porter, 2009). Notwithstanding this fact, there has been a considerable amount of progress made in the direction of ensuring accountability and transparency, especially in Britain. It started with the formation of the Corporate Governance Code in the early 1990s. Hence, in the below sections we study the Code and the legislative framework in its present form and determine its effectiveness in the face of modern scandals and financial debacles. UK Corporate Governance Code Since the 1970s, there has been an increased amount of focus on corporate governance. This may largely be attributed to the development of big multi-natio nal companies; however, the process is still in motion. As a consequence, some of the board of directors of listed companies, who form the most powerful body in the company, of the US and UK are required to be non-executive. The CEO is no longer the sole head of the company and shares responsibilities with the non-executive directors. The idea of creating an independent atmosphere where all perspectives can be included has been extended through a number of measures as a "force for good" in the economy. The "comply or explain" principle which is one of the main features of the Code has its roots in the Cadbury Committee or the Committee on the Financial Aspects of Corporate Governance report of 1992. Originally setup to come up with recommendations for financial auditing and other financial matters due to the scandals involving the Polly Peck and Robert Maxwell companies, the Cadbury Committee headed by Sir Adrian Cadbury made four important recommendations. These were with respect t o the board of directors, non - executive directors, executive directors and reporting and control mechanisms. However, these were not mandatory and the companies were free to follow their own course since it was determined that a legalistic approach would result in compliance only to a minimum basic level that negated the main aims of the Code. It was also felt that a "one size fits all" formula must not be adopted and that companies must be allowed the option to choose their own course that satisfies their unique requirements. Subsequently there was the Greenbury Report of 1998 that dealt with the remuneration of directors issue (Barker, 2008). The Code underwent a significant review in 1998 when Sir Ronnie Hampel was charged with the duty of validating the effectiveness of the existent Code. It was recommended that there was no need for radical or revolutionary changes, instead the principles needed to be extended to detailed measures for the listed companies to implement. This w as called the Combined Code on Corporate Governance which contained two levels of prescriptive practices, one of which was a set of detailed provisions and the other was a set of open - ended principles. The companies were similarly required to present a two level declaration of the compliance of the above measures in their annual report. The Code underwent another review in 2003 following the Higgs and Smith report which added another layer of compliance norms to the existing Code. It was made up of high – level main principles, mid –

Relationships with external care providers Essay Example for Free

Relationships with external care providers Essay Cultivating and nurturing relationships with outside care providers and researchers who are involved in a church’s social programs is easy to forget; it can fall by the wayside as a busy pastor tries to juggle many balls, and it is easy to delegate these programs to willing volunteers or outside help. However, study after study has emphasized the importance of pastoral involvement in social programs as a factor for their success. The congregation trusts the pastor implicitly: they trust his judgment and will follow his lead. A pastor who remains interested and enthusiastic about social programs, with as much active involvement as his time allows, will produce a congregation which is interested in and enthusiastic about its church’s social programs, willing to support them and utilize them if they are in need. The pastor can also help ensure success of a social program administered by outsiders by helping the outsiders to understand the cultural norms, traditions and history of the church. This is particularly important in a church where there are significant mental health programs in place; maintaining ties to the formal care system , and gaining the knowledge required to pre-screen congregants and help provide referrals to formal care services when required. CONCLUSION The Black church has developed a unique tradition of holistic care for its congregants. In an atmosphere of slavery, oppression, inequality and uneven or nonexistent access to formal services, the extended family and the care services provided by the church has been invaluable in preserving the physical and mental health of African-Americans. Today, this tradition continues with formalized social programs as well as informal care networks; areas such as community health care, mental health, youth services, and economic and literacy initiatives as well as traditional pastoral care continue to provide an essential resource to congregants who are still underserved and suffer disproportionately from social ills. In order to ensure that the congregants of his church have the best chance at health and secular success as well as spiritual well-being, the pastor of the Black church must determine the best social programs to emphasize, and facilitate the implementation of these programs to the best of his ability. REFERENCES Adkinson-Bradley, Carla, Johnson, Darrell, Sanders, JoAnn, Duncan, Lonnie, Holcomb- McCoy, Cheryl. â€Å"Forging a Collaborative Relationship Between the Black Church and the Counseling Profession. † Counseling and Values 49 (January 2005):147-154. Blank, Michael, Mahmood, Marcus, Fox, Jeanne, Guterbock, Thomas. â€Å"Alternative Mental Health Services: The Role of the Black Church in the South. † American Journal of Public Health. 92. 10 (October 2002): 1668-1672. Borg, Walter R. Educational Research. New York: David McKay Co. , 1963 Drake, St. Clair and Cayton, Horace. Black Metropolis: A Study of the Negro life in a Northern City. New York: Hartcourt, Brace World, 1970 Ferguson, Everett. â€Å"Factors leading to the selection and closure of the New Testament Canon Debate. †. in The Canon Debate. Eds. L. M. McDonald J. A. Sanders. Peabody, MA: Hendrickson Publishers, 2002. Ferman, Gerald S. , and Jack Levin. Social Science Research a Handbook for Students. New York: John Wiley and Sons, 1975. Isaac, Stephen. , and William B. Michael. Handbook in Research Evaluation. 2d Ed. San Diego, CA: Robert R. Knapp, 1988 Lewin, Kurt, â€Å"Action Research in Minority Problems,† Journal of Social Issues. 2, no. 4. 1948. Markens, Susan, Fox, Sarah A. , Taub, Bonnie, Gilbert, Mary Lou. â€Å"Role of Black Churches in Health Promotion Programs: Lessons from the Los Angeles Mammography Promotion in Churches Program. † May, 2002. 92(5):805-810. Miller, Kelly. Radicals and Conservatives and other essays on the Negro in AmericaNew York:Schocken Books, 1968.

Reflective Essay on Developing Care Skills

Reflective Essay on Developing Care Skills Part B Value 1 : Caring One of the values that I had learnt is caring. Caring meant concern about others. Caring for others starts from taking initiative to approach people with sincerity, care for them, to know them and care for their feelings. If everybody in this world does not care about each other, they will become selfish and do not have friends. Therefore, we must care for each other, so that everyone in every corner of the world is able to feel the warmth. As a future nurse, I must be more caring for my patients. I should not only be concerned about the diseases on the patients, but also concerned about psychological reactions of the patients. I believe that one warm word, a gentle attitude, a friendly expression can encourage patients to speak out the truth and this may facilitate the nurses to find out patients’ psychological problems. By this, I believe that I can understand my patients very well. During my Primary 3, I always asked my classmates why they did not want to make friend with me and they told me I was very selfish and arrogant. I knew that they always bad- mouthed about me. I knew the reason, but I did not bother it. I was so stubborn and did not want to change it. For me, I thought that it was not my fault. I blamed them for ignoring my feeling. In childhood, I was this kind of person, a very rebellious person. Time to time, I realized that I was quite lonely. At this time, I was very upset. Consequently, I told my dad about my problem. My dad was listening to my complaint patiently and he even did not scold me. He just smiled and told me I must change my attitude towards people around me. He wanted me to imagine the feeling if I have a friend with a bad attitude like me. He also told me that people will treat us for what we had done for them. He wanted me to be more caring about others’ feelings. I agreed to what he said. From that time, I just realized th at how bad I was. I did not want to continue to be like that anymore. I want to change! I want to be a caring person. I must care about people’s feelings. My dad and my classmates had changed me. After changing the attitude, I gained back my friends. The happiness was beyond description. Till today, I am still very grateful to them. Without them, I think I was still behaving like what I had done before. Value 2 : Responsible Another value that I had learnt is responsible. Responsible meant to complete the duty with a high spirit. Someone who is responsible will not make any excuses. In any case, we will always be faced with several factors beyond our control and irresponsible people tend to blame on these factors, take them as an excuse. To be a responsible people, we should make sure that we do not go the same way. As a future nurse, I must be responsible to my patient. By this, I must fully grasp my patient’s condition, care and treatment. Be a responsible nurse, I must closely observe patient’s symptoms and signs and identify changes in the disease as well as provide an effective intervention for medical diagnosis. I must not only alleviate the suffering of the patient, but also obtain the patients trust, give the patient a sense of security. It was happening during my secondary school time. It was still fresh in my memory. He is the one whom I admired the most. He is just a cleaner, but his spirit cannot get out of my mind. I truly admired his hardworking from my bottom heart. He had given me a deep impression until today I still cannot forget him. The first time I saw him was on the way going home from school. I still remembered it was raining cat and dog that day. People on the street all dressed in a raincoat and hurried home under the umbrella. At this time, I saw a huge rubbish heap next to my house. There was a man standing there. â€Å"Who is in there? It was raining heavily. It should not be a cleaner at there, right? † I mumble. With questions, I walked past. I cannot believe that I saw an uncle with a dusty face, wearing a tattered raincoat. He was very carefully cleaning up the rubbish. I was surprised by his action. I had never seen a cleaner still working in the heavy rain before. â€Å"Uncle, why ar e you still working in the heavy rain? You can do it tomorrow. Why are you working so hard?† I asked him. â€Å"No, I am just unhappy if I do not clean it by today. Then, there will be more bacteria growing and it was smelly as well as affecting our health.† he answered. This time, I was stunned. He was very responsible in his job. Since then, I have never seen him, but his spirit had inspired me to be a responsible person. Part C During my life journey, I had learnt the value of caring. I learnt I should care about my health. Health is the valuable asset. For having a healthy lifestyle, I must care about my eating habits. First of all, I must eat at least two servings of vegetables and one serving of fruits every day. Eating more vegetables and fruits can gain vitamins, strengthen the immune system and even reduce the chance of illness. On the other hand, breakfast is the most important meal, if we do not eat breakfast, we will lack of energy for the day and over time it will be harmful to the body. Moreover, a snack is a big killer. Snack contains much of salts, sugar and chemical components which may cause a lot of problems to our body. I also must exercise at least twice a week in order to achieve the effect of exercise. I also had learnt the value of responsible. Be a responsible person, I do not smoke. Smoking is harmful to our health and it may even causes lung cancer and other diseases. Not only that, I also must have a good mind state to evaluate myself properly and deal with the pressures of my life. I must be an optimistic, cheerful and open-minded attitude to life. On the other hand, I must also set a target to establish good relationships with people around me and also actively participate in social activities. This will help me to maintain my mental balance. Furthermore, I also practice meditation every day. Meditation can promote blood circulation and even relieve the stress. It is a good way to make myself to calm down. Part D During my clinical attachment in Tan Tock Seng Hospital, I met a patient named Mr. Khoo. He is a Chinese and his dialect is Cantonese. He now aged 60. I am also a Cantonese. So, sometimes I spoke Cantonese with him. He was admitted to the hospital because of foot ulcers which was caused by diabetes mellitus. Before he was admitted to the hospital, he stayed in Ren Ci Community Hospital. His left leg was amputated. During our conversation throughout one week time, he had told me his life experience. He had suffered from diabetes for 5 years. He had eaten a lot of hypoglycemic drugs. He told me that he did not take care of his health condition since young. He liked to drink Coke. He basically did not do any exercises. Due to long-term work at the grassroots level and slept late, so he accustomed not to get up early in the morning. Due to sitting in the office for a whole day or business meetings, he basically did not participate in any sports. He also told me he liked to eat meat. Duri ng the past, he had always eaten lamb stew as his supper before going to sleep and he usually did not take his breakfast the next morning. Due to the long-term excessive meat, plus he did not like to eat vegetables, fruits, beans and his daily staple food are meat, so his weight in the past 10 years has severely excessive. He suffered from diabetes because of the previous living conditions. From his life experience, I noticed that healthy lifestyle plays a vital role in our life. (1419 words)

A Tale of Two Cities Essays: A Critical Analysis -- Tale Two Cities Es

A Critical Analysis of A Tale of Two Cities Three Works Cited A Tale of Two Cities is a novel that is very complex and intense. Once you get to know the characters you can feel what they are going through and form a kind of bond with them. A Tale of Two Cities grabs the reader’s attention with the history of revolutions in the nation and the generations of that time, but it also keeps the reader reading with a sense of a pure violence that is hard to create. The combination of critical literary and historical methods brings out the novels complex structure and intense impact on the reader. Dickens brings out the historical side of the Victorian age with examples and details of the French Revolution and Victorian Revolt. Lee Sterrenburg says that Dickens' vision of the revolution was probably influenced by "a personal day dream only he can fathom. But he is able to render his day dreams in terms of a publicly Victorian Iconography". (Hutter 37) The Victorian revolt happened late in the Victorian Age and was a turning po...

Cruel and Unusual Punishment: the Death Penalty

Cruel and Unusual Punishment: The Death Penalty I remember watching the movie Dead Man Walking; it was about this man named Matthew Poncelet who allegedly raped a girl and killed a teenage boy. Poncelet pleaded not guilty, but was convicted as a murderer and put on death row. He asked for several appeals stating that Carl Vitello, the man he was with at the time, was the one that should be at fault. Poncelet seems very convincing that it wasn’t him, but at the end, the courts had enough evidence to grant Poncelet the retribution of execution.The movie has me questioning America’s justice system; what if someone was actually innocent? Is it right to kill someone as a consequence for their wrong doing? To some, it seems like the right thing to do. If someone breaks the rules you simply punish them. But how should we carry out these punishments? When eight-year-old Billy steals a candy bar from Seven Eleven, you can bet that one of the parents will deliver some whippings. In Texas, when I was in elementary school, I started a fight, and as a result I got sent to the principal’s office and received three licks with a paddle.So where do we draw the line? At a higher level, what happens to me if I kill someone? Since the beginning of time, societies in almost every culture and background have used capital punishment or physical chastisement as a consequence for the killing of others. But, we shouldn’t be doing this anymore; life is too valuable. Even though some people have made mistakes in their lives, its time for the United States to free the judicial systems from their power to take peoples life’s as a consequence for people taking the life of another. In 1972, with the Furman v.Georgia case, the Supreme Court recognized that capital punishment was indeed a roll of the dice, and as a consequence held that as practiced it violated the Cruel and Unusual Punishment clause of the Constitution's Eighth Amendment. Justice Stewart decl ared that the death penalty was cruel because it is â€Å"wantonly and freakishly imposed,† and it was like â€Å"being struck by lightning† (Hull). Justice Douglas, agreed and stated that the death penalty was unusual because â€Å"it discriminates against someone by reason of his race, wealth, social position, or class† (Hull).Justice Byron White, a man who favored more executions, agreed that he noticed, that among the hundreds of federal and state criminal cases that could have resulted in the death penalty, â€Å"only a handful of defendants were actually selected for execution† — making the system â€Å"so totally irrational as to be based on luck† (Hull). The decision removed power from the states to enforce the death penalty, and moved the 629 inmates off death row.For a few years, the death penalty remained illegal because the Justices that were on the Supreme Court at the time concluded that executions violated the Eight and Fourte en Amendments, citing cruel and unusual punishment. However, with different terms, in 1976, the Supreme Court reversed itself with Gregg v. Georgia and reinstated the death penalty to state hands. Nevertheless, this is a prime example of how the Supreme Court can change laws and set precedents by the way they interpret our Amendments.The Supreme Court is in place to dissect, and analyze the Constitution to decide what the Framers meant, and in 1972, the perspicacity of the Justices resulted in the most humane decision ever made; people where being deprived from life by serving life imprisonments instead of being executed. Since 1976, the United States has executed 1,295 people, and there are currently 3,189 people on death row (DPIC). But all murderers haven’t had the same fortune, because of Gregg v. Georgia, some states enforce the death penalty and others don’t. There are currently 33 states in the U. S. ho currently support and implement capital punishment, and 17 states who oppose. (DPIC). Murderers in non-capital punishment states can kill with the highest punishment being life in prison; but if that same murderer resided in another state, he would have the opportunity, depending on the case, to be sentenced to execution, via lethal injection. The problem here lies, that there is no consistency when it come to punishing the murderers. If a murderer lives in the U. S. the reprimands should remain the same for everyone; the penalties shouldn’t differ because what climate a killer prefers living in.The laws that we have in place now, means that if I wanted to go on a killing spree, and I didn’t want to die because of it, I would simply move from a death penalty state to a free death penalty state and make my moves there. It’s not right to pick and choose something of this magnitude. Everyone in this nation should be treated equally when it comes to a life or death situation. In 2007 at the State Bar of Wisconsin Annual Con vention in Milwaukee, pro- and anti-death penalty activists gathered to debate over the death penalty. During this debate, James P. McKay Jr. an assistant state's attorney with the Cook County State's Attorney's Office in Chicago, and a pro-death penalty supporter, stated in defense that he â€Å"absolutely believes that the death penalty brings justice to a murder victim's family† (Pribek), and that he has â€Å"never called for the death penalty in a case for political purposes† (Pribek). Professor John C. McAdams, a political science professor of Marquette University in Milwaukee, and an anti-death penalty supporter, fired back with, â€Å"The state should not implement the death penalty because of its irrevocability.Whether the state is literally taking a prisoner's life, versus locking him or her up for life, the state has taken that person's life by vanquishing his or her freedom† (Pribek). Moments after, McAdams closed out the debate with the crowd on his side, stating, â€Å"If I were on the Supreme Court, I'd say that the death penalty is cruel and unusual punishment† (Pribek). Although some death penalty advocates consider themselves the voice of the innocent victims and their families, McAdams made a very notable point.Penitentiaries don’t have to eradicate the murderer to serve justice. But you can end a life; sentence the murderer to serve permanent incarceration, and you will deprive them from freedom, or in other words, life; which in return satisfies the amendments. Yet, â€Å"we the people†, continue to put the power of life or death into the hands of fallible, sometimes prejudiced, narrow-minded people and ask them to play God and determine who’s worthy to live a life that we did not bestow upon them.Sentencing someone to life is the most reasonable solution in more ways then one. There have been 140 exonerations since 1972, and from 2000 to 2007 there has been an average of 5 exonerations per year — innocent people suffering for no reason (Woodford). The average time between the sentencing to death of the once sought guilty, to their proven innocence, is 10 years. If U. S. citizens could find it in their hearts to come together and drop down to the humanitarian level, there could be change in the system with awareness, and spread of word.There has to be other people who share the same feelings, and cringe at the thought of possible government killings toward non-guilty — it’s unsupportable. Its mind boggling to note that there has been 140 non-guilty offenders put in prison with the presumption that they are going to die, and then some years later, they are freed. The probable innocent killing can easily be solved by sentencing presumable murderers to life without parole. The death penalty is much more expensive than life without parole because the Constitution requires a long and complex judicial process for capital cases.If the death penalty was re placed with life without parole, an immense amount of money would be saved. According to a California Commission report in 2008, California could save $1 billion over five years by replacing the death penalty with permanent imprisonment (Woodford). The report stated — with reforms to ensure a fair trail to the current system in place, the death penalty would cost California an estimate of $232 million a year and the cost for a system that imposed lifetime incarnation instead of the death penalty would only cost $11. 5 million a year (Woodford). Two birds with one stone.The evidence for capital punishment as an uniquely effective deterrent to murder is especially important, since deterrence is the only major pragmatic argument on the pro-death penalty side. The theory is, if murderers are sentenced to death and executed, potential murderers will think twice before killing for fear of losing their own life; what is feared most, deters most. In 1973, Isaac Ehrlich, statistician who, after looking at national homicide rates between 1930 and 1970, established an analysis which produced results showing that for every inmate who was executed, 7 lives were spared because others were deterred from committing murder.But this however, has been proven inconclusive, and results cannot be duplicated by other researchers. Then in 1997, George Pataki, the Governor of New York state at the time, stated during the anniversary of reinstating death penalty, â€Å"To fight and deter crime effectively, individuals must have every tool government can afford them, including the death penalty† (Paraki). The governor made strong relations with the death penalty and the potential of installing fear in other potential murders.Pataki continued with strong regards to the deterrence theory after mentioning that the death penalty was a key contributor to the recent dramatic drop in violent crimes — â€Å"In New York, the death penalty has turned the tables on fear and p ut it back where it belongs-in the hearts of criminals. I know, as do most New Yorkers, that by restoring the death penalty, we have saved lives† (Pataki). I do not feel that execution best punishes criminals for their acts.Instead, in my opinion, the administration of the death penalty should end because it does not deter crime, it risks the death of an innocent person, it costs millions of dollars, it inflicts unreasonable pain, and most importantly it violates moral principles. The inconsistency doesn’t make sense either, according to Nearly everyone that has been summoned to death row, is spurred from to According to our Bill of Rights, I cannot be deprived of life without due process of law (US Const. , amend. V). So if the process of law is carried out, the courts can decide to kill me if my crime is severe enough to correspond with capital punishment.But, according to the eighth amendment, I’m protected from cruel and unusual punishment ? isn’t kill ing someone cruel and unusual? Did our Framers mean that the death penalty has to be humane, or did they mean the person has to be imprisoned for life? Is it right for someone you have never met to define these so called â€Å"rights† and never be consistent with their definitions? So here we are with a lot of questions and no right answers! Yes, Poncelet did commit a crime and he should pay; but how can someone that didn’t put you in this world, take you out?The death penalty is cruel and unusual. Why can’t the court system just sentence someone to life in prison? I believe if you take the life of another, it is a form of cruel punishment. In my eyes, it could be a violation of the eighth amendment. Our fifth amendment states, that with the processes of due law, they can deprive us of life. But how can someone construe that as killing us and taking our life? The judicial courts should have interpreted this as putting someone in prison until they die. If youâ₠¬â„¢re imprisoned for the rest of your life, then you have been deprived of life.This should be enough justice. It’s not like someone will be enjoying their time. I don’t see how the people that operate the death penalties can sleep at night; killing someone because they killed just isn’t right. They should actually make a certain prison for those who have been deprived of life, the ones who have killed. The prison should have the inmates locked up in a small dark room for 24 hours a day with no contact with anyone, no bed, no blanket, just a toilet and pictures of the victims engraved into the walls of their cell.At least this way, the killer could regret what he/she did and maybe feel some sort of remorse. It would drive the person insane. It’s also messed up for the court system to appoint a state lawyer to defend you and call that a fair trail. No lawyer really cares if you win or lose the case all they care about is the money. If one is well off when it comes to money, then of course one can afford a nice experienced lawyer that would probably bust his ass and do anything to win the case, for the reason that he would probably get more money. But if you can’t afford a lawyer, they will be happy to appoint you one.He is probably making salary and his pay isn’t justified if you win or not. If your pay doesn’t fluctuate, then there is no drive; he’s not going to work as hard and not give the case as much thought. When it’s all said and done, the appointed lawyer has nothing to lose. Maybe it’s just your luck and he is a newbie and doesn’t have any business in a case involving a murder. If they want to make it a fair trail, why can’t they pay for a top notch individual lawyer who excels in that position? We should be able to pick our own, so then at least the poor person can have a chance.I mean when you’re talking about someone’s life you don’t want any Jo e Blow defending your case. Here is a statistic for you; according to American Civil Liberties Union â€Å"Approximately 90 percent of those on death row could not afford to hire a lawyer when they were tried† (Tabak). Is it okay that only some states have the death penalty? I don’t think so. If I live in Washington State and go to Alaska to kill a man, under Alaska law I will not receive capital punishment (DPIC); the worst I would get is life in prison. But if I would have stayed and did my killings in Washington, I would be put on death row (DPIC).If the United States isn’t consistent with who dies and who doesn’t, then obviously there’s something wrong. It just doesn’t seem right to pick and choose something of this magnitude. Everyone in this nation should be treated equally when it comes to a life or death situation. Here’s yet another problem that I have found: weren’t we all suppose to have unalienable rights– ri ghts that can never be taken away from us; the right to life, liberty, and pursuit of happiness? But wait; in some states they can take away our life if the crime seems bad enough.I’m no law expert, but this doesn’t seem to mesh together either. I thought the government could only suppress these rights by dictators and tyrants under oppressive regimes. The most controversial subject when talking about capital punishment is that the executioners are actually committing a crime that should put them on death row too. It’s probably the most obvious debate, but seriously, how can the same group of people who just told you that killing is illegal, turn around and kill people? That doesn’t sound fair, does it? Shouldn’t the law be equal for everyone?If murdering is illegal, then how in the hell are these people getting away with this? There’s no reason why they should get exempt from this law. They are just as bad as the criminal who committed crim e. There’s another example of how inconsistent this â€Å"act of justice† (Volpe) is being used. Two wrongs don’t make a right I don’t care how fucked up the situation may be. This law simply contradicts itself. I know I stated that it was hard to choose a side, but while writing this paper, I am confident that I oppose the whole capital punishment bullshit.Yeah, I get where people are coming from, but the reasons to not believe in the death penalty overweigh the reasons to believe in the death penalty. The only way to solve this disagreement is to actually go in and define the wording in the fifth and eighth amendments. The Framers left the Constitution open, leaving the interpretations flexible to the generations of justice to come. Once our judicial government can come to an agreement on the wording in the Constitution, then maybe we can decide if we want to continue killing people by stooping down to the criminal level.Kartha, Deepa. â€Å"10 Pros an d Cons of Capital Punishment. † Buzzle Web Portal: Intelligent Life on the Web. 5 Dec. 2009. Web. 25 Oct. 2010. . Tabak. â€Å"Loyola of Los Angeles Law Review. † American Civil Liberties Union. 1984. Web. 25 Oct. 2010. . http://www. jmu. edu/evision/archive/volume2/Volpe. pdf Works Cited DPIC. â€Å"Introduction to the Death Penalty. † Death Penalty Information Center. 2012. Web. 1 June 2012. Hull, Elizabeth. â€Å"Guilty On All Counts. † Social Policy 39. 4 (2010): 11-25. Academic Search Complete. Print.Pataki, George E. â€Å"Death Penalty Is a Deterrent. † Ed. John Hillkirk. USA Today [McLean] 1 Mar. 1997. Print. Pribek, Jane. â€Å"Pro- And Anti-Death Penalty Advocates Square Off At State Bar Of Wisconsin Annual Convention. † Wisconsin Law Journal (Milwaukee, WI) (n. d. ): Regional Business News. Print. Volpe, Tara. â€Å"Capital Punishment: Does Death Equal Justice? † Jmu. edu. 2002. E-vision. Web. 10 June 2012. Woodford, Jeanne. â€Å"10 Reasons to Oppose the Death Penalty. † Death Penalty. Death Penalty Focus, 2012. Web. 11 June 2012.

Age Affects Drug Metamorphosis Essays

Age Affects Drug Metamorphosis Essays Age Affects Drug Metamorphosis Essay Age Affects Drug Metamorphosis Essay Introduction There has been a batch of work and research carried out since the find that age affects drug metamorphosis which can take to toxicity in the 1950s and 1960s. Therefore more cognition and understanding about how drug metamorphosis affects age is critical, which led to the happening out of the of import function of the liver, cytochrome enzyme household, genetic sciences and transporter systems in drug metamorphosis. Age was discovered to hold singular consequence on most of this phenomena involved in drug metamorphosis such as liver volume decrease, lessening in activity of some cytochrome enzymes household. However, the job of acquiring healthy liver tissue of homo and some limitation ethically have limited the surveies of drug metamorphosis effects on age in relation to toxicity. There are legion factor that besides influence the toxicokinetics of drugs in homo. Adult population have more advantage in footings of surveies affecting drugs metamorphosis than the older population and p ediatric population due to hazards involved and ethical grounds in surveies on new drugs which discourage testing of drugs in the older and pediatric population. Changes in drug metamorphosis may be due to differences in toxicokinetics which include soaking up, distribution, metamorphosis or elimination. There are legion variety meats and system that diminution with age and besides undeveloped variety meats and systems in babies or pediatricss affects drug metamorphosis has consequence of this conditions. Advancing age consequences in cut down stomachic acid secernment, stomachic voidance, GI mobility, surface country for soaking up, liver size and map, nephritic map, thin organic structure mass, entire H2O content, serum albumen, cardiac end product and increase organic structure fat which affect straight or indirectly drug metamorphosis and can take to toxicity. Drug METABOLISMS Metamorphosis is a procedure that cause drugs to go more H2O soluble in order to readily take them from the organic structure after they have perform their action in the organic structure. This procedure takes topographic point chiefly in the liver cells and produces metabolites which are non active and sometimes non-toxic, although some metabolites may be toxic. There are drugs that their parent drug are in active and the metabolites produced are active. The mechanisms of drug metamorphosiss are divided into stage I and phase II. Phase I reactions involves structural alteration of drug molecules and stage II reaction dwelling of junction with a more H2O soluble compound. Oxidation, decrease and hydrolysis are chief reaction happening in stage I with engagement of cytochrome p450 enzymes an other enzymes are besides involved in oxidative metamorphosis ( Strolin Benedetti, M. et Al ) . Maturational alterations occurs from birth in both stage I and phase II metabolic tracts which is no rmally non to the full mature at birth. The liver is most of import organ for drug metamorphosis quantitatively and signifiers about 6 % of the organic structure mass at birth but around 3 % of the organic structure mass in the grownup. Growth is associated with decrease in blood fluxing into the liver and liver volume accordingly ensuing in reduced metabolic clearance with drugs that require high hepatic remotion whereas drugs with low hepatic remotion are normally less removed which can take to toxicity. Depending on the enzyme system involved, there can be production of low or high plasma concentration of active rule due to different capacities to metabolise drug in the paediatric or older people than in grownup. There are healing agent in kids that produces metabolites whereas this metabolites are non present usually in grownup and the metabolites may be the cause of efficaciousness and/or toxicity seen with disposal of drug in kids for illustration kids having Elixophyllin produces caffeine ( Olive et Al. ) and other illustrations of healing agent that differ in metabolite production are paracetamol, salicylamide, Chloromycetin, valproic acid and Tagamet. There is besides different in degree of look of metabolites in kids compared to adult although they express the same enzyme complement but there is no cognition of illustration of metabolite production non usually present in grownup that are seen in the older population. Few exclusions occurs though in most instances because differences between the kids and grownups are in ratio of metabolite compared to the parent drug instead than metabolites that are unevenly specific to the paediatric. PHASE IREACTIONS OXIDATIVE ENZYMES CYTOCHROME P450 ( CYP ) SYSTEM The oxidative metamorphosis of many drugs and chemicals are catalyze by cytochrome p450 isoenzyme superfamily that consist of over 50 proteins. The enzymes are present in the smooth endoplasmic Reticulum of the liver and other tissue in their lipotropic membrane which can be isolated and they become cysts called microsomes. Different cytochrome p450 household are responsible for different metamorphosis for illustration cytochrome p450 households 1-4 are responsible for foreign compounds metamorphosis while the other cytochrome p450 households are responsible for endogenous substrates metamorphosis. The metabolic activation of many chemical carcinogens and toxins that undergoes metamorphosis and used clinically are besides the duty of cytochrome p450. CYP1A There are two isoforms of CYP1A subfamily viz. CYP1A1 AND CPY1A2. CYP1A1 are chiefly extra-hepatic. CYP1A2 is concerned chiefly with the metamorphosis of paracetamol, caffeine, Elixophyllin, impramine hydrochloride, aromatic aminoalkanes, Coumadin and acetophenetidin. All demethylations of N-1, N-3, N-7 and pealing hydroxylation of C-8 in the metamorphosis of caffeine and Elixophyllin are besides the duty of CYP1A2 and other CYP isozymes like CYP3A4/5, CYP2A6 and CYP2E1 besides take portion in these reaction ( Oesterheld et al, Kalow, W. and Tang et al. ) . In pediatric, CYP1A2 is non normally noticeable until one to three months infant age and its additions until about three old ages but remains the same with big degree afterwards. Demethylation of caffeine N-3 depends on CYP1A2 in newborns, babies and grownups but N-3 demethylation is more of import in immature babies. Caffeine metabolic tract matures with postpartum age particularly with entire demethylation, demethylation of N-7 and N-3 demethylation whereas demethylation of N-1 show no fluctuation but ripening occurs at one and half old ages of age. Hydroxylation of C-8 is normally developed at one month in few babies than in grownups. The activity of most demethylation was found to be lower in newborns and babies than grownup and diet of babies besides affect development of CYP1A2 activity ( Blake, M.J. et Al ) . There is lessening in activity of CYP1A2 in aged with caffeine. Most of this fluctuation leads to toxicity and it s dose dependent excessively. CYP2A There are three isoforms of this subfamily viz. CYP2A6, 2A7 and 2A13 ( Hakkola, J. et Al ) . CYP2A6 is chiefly involved in contact action of coumarin 7-hydroxylation ( Pelkonen, O. et Al ) . Urinary elimination of 7-hydroxycoumarin is about the same in kids of six to fourteen old ages and grownups but the rate of riddance is unchanged or reduced for CYP2A substrates in the aged which can do toxicity in relation to dose given. CYP2A6 is non seen in fetal liver. CYP2C The isoforms of this subfamily are CYP2C9, CYP2C19 and CYP2C8. They are involved in metamorphosis of assorted curative agent for illustration anti-inflammatory drugs ( non-steroidal ) , antiepileptics, Coumadin, propranolol, Valium etc and might lend to metamorphosis of endogenous agents e.g arachidonic acid. CYP2C isozymes is noticeable early in neonatal period, one month degree is normally about tierce of grownups and remains the same until about one twelvemonth of age. From birth there is interindividual fluctuation in CYP2C9 protein and activity until about 18years with 36 crease boulder clay five months and less fluctuation between five months and 18 old ages. Phenytoin ( antiepileptic ) and substrate of CYP2C9 pharmacokinetics is affected which can take to toxicity. Expression of CYP2C19 additions from birth for approximately five month and fluctuation of single between five months and ten old ages is about 22 creases but from ten old ages at that place is similarity in activit y and look with grownup ( Blanco, J.G. et Al ) . In the aged there is lessening in the rate of riddance of substrates of both CYP2C19 and CYP2C9 ( Kinirons, M.T. et al and Cusack et Al. ) likely doing toxicity depending on dosage. CYP2D CYP2D6 is involved in the metamorphosis of drugs like A ; szlig ; -blockers, anti jerking drugs, antidepressants ( tricyclic and non-tricyclic ) , codeine, Capoten, ondansetron etc ( Strolin Benedetti, M. et Al ) . There is addition in the protein look of CYP2D6 from few hebdomads postpartum age to about five old ages and reaches about two- tierce of the grownup degree. There is besides CYP2D6 polymorphism in kids but there is unchanged rate of riddance of substrates of CYP2D6 in the aged. Most of this change with age can impact the metamorphosis taking to toxicity and it s dose dependant. CYP2E CYP2E1 contribute to the metamorphosis of little molecules like paracetamol, aminobenzine, ethyl alcohol, N-nitrosodimethylamine ( strolin Benedetti, M. et Al ) . The enzymes rises after birth boulder clay about one twelvemonth and go approximately 40 % of big degree but reaches 100 % grownup degree between one twelvemonth and 10 twelvemonth ( strolin Benedetti, M. et Al ) . It decrease or stay unchanged with age utilizing substrates like paracetamol and chloroxazone ( Kinirons et Al and OMahony et Al. ) but recent survey shows that there is addition in CYP2E1 activity with age in work forces than in adult females ensuing in toxicity depending on dosage. CYP3A CYP3A isoforms are CYP3A4, CYP3A5, CYP3A7 ; they are the major CYP isoforms found in the liver and little bowel. They are besides involved in oxidization of legion substrates.CYP3A5 is independent of age and variably high in look ( Steven et al. ) . CYP3A4 is majorly expressed in grownup liver while CYP3A7 is majorly expressed in fetal liver. The isoforms are closely related structurally but differs in monooxygenase reaction capacity map. CYP3A7 in fetal liver is really active until after first hebdomad of birth and starts to diminish till it is absent in grownup liver. CYP3A4 is really weak or non present in fetus but rises after birth and it is responsible for biotransformation of cisapride ( serotonin 5-HT4 agonist ) which can do cardiac toxicity in newborns due to steady addition in activity of CYP3A4 in metamorphosis of cisapride that exceeds grownups value activity particularly in newborns and grownup that do nt transport hazard factor impacting them. Another CYP3A4 substrate, endovenous Versed ( ataractic ) metamorphosis is lower in newborns than in babies greater than 3months of age but as a consequence of low activity of CYP3A4 in the bowel of grownup there is addition in bioavailability of Versed following unwritten consumption in preterm babies compared to grownups ( De Wildt, S.N. et Al ) . CYP3A4 development is fastened with diet in babies ( Blake, M.J. et Al ) . In the aged there is inconclusive information about the activity and look of CYP3A but it remain unchanged or lessening with age ( Schmucker et al. ) . FLAVIN-CONTAINING MONOOXYGENASES ( FMOs ) Flavin- containing monooxygenases are critical in oxidative of assorted foreign compounds incorporating nucleophilic N, phosphorus-heteroatoms, Se, S that are NADPH dependant. There are six member cistron household of the enzyme ( FMO 1-6 ) . In the paediatric, FMO1 look was highest from 2months to 4months gestation and a mechanism coupled with construct suppressed wholly look of FMO1 within three yearss post natal. FMO3 look was non present during neonatal period but low degree was present between 2months and 4months gestation ; from one to two old ages of age FMO3 look was present and increase boulder clay about 11 old ages but from 11 old ages to eighteen old ages, there is gender -interdependence in the addition of FMO3 look ( Strolin Benedetti, M. et Al ) . There is a hepatic nothing FMO phenotype in newborn due speedy station natal suppression of FMO1 and FMO3 look delayed oncoming. MONOAMINE OXIDASES ( MAOs ) Monoamine oxidases are involved in the exogenic and endogenous compounds metamorphosis and found in the chondriosome of liver, kidney, lungs, encephalon, bowel and thrombocytes ( Strolin Benedetti, M. et al. ) . Their concentration is low in liver and higher in other tissues. The two monoamine oxidases that take portion in drug metamorphosis are MAO A and MAO B. During construct MAO A activity is really high and reduces rapidly in the first two twelvemonth of age and becomes steady afterwards. MAO B activity is low at construct, steady in early age and increases with progressing age. ALCOHOL DEHYDROGENASE ( ADH ) Alcohol dehydrogenases are cytosolic isozymes that are involved in the reversible oxidization of intoxicants to aldehydes and metamorphosis of endogenous compounds like steroids and vitamin A1. For illustration Atarax to cetirizine. There are six categories of intoxicant dehydrogenase ADH 1-6, five of the ADH 1-5 are found in adult male ( Strolin Benedetti, M. et al. ) . In newborns, there is immature development of the activity of ADH but from one to two and half twelvemonth of age, the activity of ADH is the same or greater than in grownup. There is no much difference in the activity of ADH in grownup compared to the aged. MOLYBDENUM HYDROXYLASES ( ALDEHYDE OXIDASE AND XANTHINE OXIDASE ) Aldehyde oxidase ( AO ) and Xanthine oxidase ( XO ) are involved in exogenic and endogenous substrates biotransformation. XO is involved in oxidative hydroxylation of hypoxanthine to xanthine, xanthine to uric acid and purine metamorphosis last two stairss in mammals. AO and XO are similar structurally but AO takes portion in metamorphosis of estrogen antagonist, ziprasidone, zaleplon, famciclovir, zonisamide etc. XO activity in plasma is really high in babes compared to adult and AO activity is immature until about 12months after ( Karg, E. et Al and Tayama, Y. et Al ) . XO activity is independent of age in aged. REDUCTIVE ENZYMES NADPH-CYTOCHROME P450 REDUCTASE The negatron giving spouse to CYP enzymes are flavin adenine dinucleotide ( FAD ) and flavin mononucleotide ( FMN ) contained in the cytochrome p450 reductase. NADPH cut downing enzymes are passed to the FAD of cytochrome p450 reductase and so to CYP enzymes via the FMN of the cytochrome p450 reductase. There is no much important alteration with age with NADPH-cytochrome p450 reductase ( Schmucker et al. ) . ALDO-KETOREDUCTASES Aldo ketoreductases are present in red blood cells, liver and are cytosolic enzymes involved in decrease of carbonyl groups. They besides metabolized hypolipidemic drugs ( fenofibrate ) and anti malignant neoplastic disease drugs ( anthracyclines ) . Prostaglandin E1 ( PGE1 ) are metabolized by ketoreductase. ketogroup decrease frequently produce active metamorphosis which can do toxicity with age for illustration idarubicin produces idarubicinol ( alcohol merchandise ) and PGE1 produces 13,14-dihydro-15- ketoprostaglandin E1 which is farther cut down to active compound 13, 14-dihydro-prostaglandin E1. HYDROLYTIC ENZYMES ESTERASES There is lessening in the activity of esterases in newborn than in grownup but in the aged physical failing reduces the activity of esterases particularly those with injuries, undergoing surgery, injured or ill. From 7months gestation to 12months of age, there is speedy addition in the activity of plasma arylesterase and pseudocholinesterase activity, but no important change occurs afterwards. There is disconnected addition in erythrocyte acetylcholinesterase activity between construct and 12months i.e red blood cells are non matured before construct. Ester signifiers of drugs are largely incompletely hydrolyzed in newborns due to low serum concentration that consequence e.g Erythrocin estolate, Chloromycetin palmitate ( Morselli, P.L. et al. ) . PHASE II REACTIONS Acetylation Junction with acetyl group by drugs like INH, p-aminosalicylic, p-aminobenzoic acid, sulfamezathine and toxic agent is control by activity of N-acetyltransferase ( NAT ) . in premature and neonates, there is acetylation of p-aminobenzoic acid by N-acetyltransferase1 ( NAT1 ) which increase somewhat in babies and is reduced in kids ( Strolin Benedetti, M. et al. ) . N-acetyltransferase2 ( NAT2 ) involved in caffeine and INH metamorphosis shows that in babies there are slow acetylators or fast acetylators that are non matured with caffeine and with isoniazid acetylation ripening occurs after one twelvemonth, as fast acetylors increases with age till four old ages peak. METHYLATION Junction of methyl group are the duty of S-methytransferase, O-methyltransferase, and N-methyltransferase which are involved in transportation of methyl group to oxygen-nucleophile, nitrogen-nucleophile and sulfur nucleophile. N-methyltransferases Theophylline N-7-methylation in newborn to caffeine is good matured but oxidative demethylation is deficient and matures after several months of age. Thiopurine-s-methyltransferase Thiopurine-s-methyltransferase ( TPMT ) is involved in the metamorphosis of azathiopurine ( converted to 6-MP ) and catalyzes thiopurines metamorphosis e.g 6-MP ( antiblastic drug ) . TPMT is a cytosolic polymorphic enzyme which is cistron specific and are present in many tissue and red blood cell. In pediatric, there is high activity of TPMT in approximately 90 % of the population, approximately 8 % have intermediate activity and 0.3 % have low activity. Inactivation by TPMT which affects the efficaciousness of 6MP in single with low TPMT activity experience terrible toxicity with 6MP standard doses. GLUCURONIDATION There are assorted UDP glucoronsyltransferase ( UGT ) isozymes present in human. Glucuronidation in pediatric ranges adult degree when they are 12weeks to24weeks old, 12months, 36months or subsequently in age depending on the drug. At 12weeks of age, hematoidin glucuronidation which is the duty of UGT1A1 isozymes approach big degree but occurs at really low degrees in newborns liver. For illustration Chloromycetin with lower glucuronidation in paediatric can take to toxicity because glucuronidation is clearly deficient in most premature babes and mature babes. Therefore high concentration of unmetabolized Chloromycetin may increase in sum taking to serious toxicity which cause go arounding prostration or gray baby syndrome with standard dosage per bodyweight. These prompt the more surveies and the dosage was regulated on weight, gestation and postpartum age footing. UGT2B7 besides metabolize Chloromycetin and some UGT isoforms besides eliminates it. 3-glucuronides ( M3G ) and 6-glucu ronides ( M6G ) are formed as a consequence of UGT2B7 metabolising morphia. There is addition in the quality of morphine glucuronidation activity after neonate age. For illustration there is addition in epirubicin glucuronidation activity with age and riddance of epirubicin ( malignant disease intervention ) is majorly by UGT2B7 glucuronidation. In kids of 7 to 10 twelvemonth, there is deficient glucuronidation of paracetamol and salicylamide in correlativity with grownups ( Alam, S.M. et al. ) . UGT1A6 is the chief glucuronidation isozymes of paracetamol although UGT1A1 and UGT1A9 besides takes portion in the glucuronidation ( Court, M.H. et al. ) . Strassburg et Al. observed that UGT1A1, 1A3, 2B15, 2B4, 1A4, 2B7, 1A6, 2B10 and 1A9 are present after 6 months of age. There is different in look of UGT1A1, 1A6 and 2B6 protein but lower messenger RNA look for UGT2B4, 1A9 was seen. Hepatic glucuronidation activity in 1-2years is low compared to grownups for the undermentioned drugs e.g buprenorphine, Elavil, isobutylphenyl propionic acid, theelin, 4-tert-butylphenol. Acyl co-enzymes A, phospholipid content, fatty acid with long concatenation and membrane factors may be responsible for enzymatic activities differences between pediatric and grownup. In aged, there is decreased glucuronidation of lamotrigine and riddance of Serax, retigabine by UGT activity. SULFATION The sulfate junction of several endogenous and exogenic chemicals by sulfotransferase ( SULT ) cistron household that encodes about 11 major enzymes utilizing 3-phosphoadenosine-5-phosphosulfate ( PAPS ) . In peadiatric, there is ripening of sulfate tract at construct which is the chief metabolic path in baby and kids for salicylamide and paracetamol ( Alam, S.M. et al. ) . For illustration in morphine metamorphosis sulfate junction can counterbalance for the less-matured glucuronidation. Junction WITH AMINO ACIDS Biotransformation of some compounds is dependent on the junction of foreign compounds of carboxylic acids with endogenous amino acids. In worlds glycine, glutamine and taurine are aminic acids that undergoes junction often. In pediatric, junction with glycine additions from construct to kids age and is the major tract for metamorphosis of salicylates in newborns ( strolin Benedetti, M.et al. ) . Formation of hippuric acid by glycine junction of benzoic acid is present but deficient in preterm babes. Junction WITH GLUTATHIONE Cytosolic glutathione S-transferase ( GST ) is responsible for junction of glutathione. Catalysiss of conjugate of different electrophiles with decreased glutathione is the major manner by which GSTs metabolize carcinogens, exogenic and endogenous toxins. In pediatric within 12-24months, there is addition in GSTA1 and GSTA2 look to adult degree with norm of 3 crease and GSTM look increased to about 5 crease to adult degree at construct. In grownup liver there is no GSTP1 but it is present in newborns. GST activity and GSTP1 degree in female merely showed of import addition from less than 50 old ages to over 70 old ages ( Hoensch, H. et al. ) . Decision The increasing fluctuation between single in enzymes activity involved in drug metamorphosis coupled with other physiological factors make it hard to distinguish age effects on drug metamorphosis in relation to toxicity but a good cognition about the drugs pharmacokinetics is really of import to cognize patient population that requires dosage accommodation in order to forestall toxicity ( acute or chronic ) after exposure. A better apprehension of the specific drug metabolising enzymes with age fluctuation is besides critical in ordering drugs to patient population and in development of drugs in the patient population. Most drugs metabolized through the cytochrome p450 enzymes decreases with age every bit good as the nephritic riddance of most drugs decreases with age which can take to toxicity. Mentions Strolin Benedetti, M et Al. ( 2005 ) Differences in soaking up, distribution, metamorphosis and elimination between the paediatric and the grownup population. Expert Opin. Drug Metab. Toxicol. 1, 447-471 Cazeneuve, C. et Al. ( 1994 ) Biotransformation of caffeine in human liver microsomes from foetuss, newborns, babies and grownups. Br. J. Clin. Pharmacol. 37, 405-412. Zeeh, J. et Al ( 1996 ) Influence of age, infirmity and liver map on the pharmacokinetics of brofaromine. Eur. J. Clin. Pharmacol. 49, 387-391 Simon, T. ( 2001 ) Variability of cytochrome P450 1A2 activity over clip in immature and aged healthy voluntaries. Br. J. Clin. Pharmacol. 52, 601-604 Kinirons, M.T. and OMahony, M.S. ( 2004 ) Drug metamorphosis and ageing. Br. J. Clin. Pharmacol. 57, 540-544 Cusack, B.J. ( 2004 ) Pharmacokinetics in older individuals. Am. J. Geriatr. Pharmacother. 2, 274-302 Koukouritaki, S.B et Al. ( 2004 ) Development look of human hepatic CYP2C9 and CYP2C19. J. pharmacol. Exp. Ther. 308, 965-974 Blanco, J.G. et Al. ( 2000 ) Human cytochrome P450 maximum activities in paediatric versus grownup liver. Drug Metab. Dispos. 28, 379-382 George, J. et Al. ( 1995 ) Age but non gender selectively affects look of single cytochrome P450 proteins in human liver. Biochem. Pharmacol. 50,727-730 Schmucker, D.L. ( 2001 ) Liver map and Phase I drug metabolim in th aged. A paradox. Drugs Aging 18, 837-851 Ishizawa, Y. et Al. ( 2005 ) The consequence of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics. Clin. Pharmacokinet. 44, 1179-1189 Foglia, J.P et Al. ( 1997 ) Plasma degrees of citalopram enantiomorphs and metabolites in aged patients. Psychopharmacol. Bull. 33, 109-112 Stevens, J.C. ( 2006 ) New positions on the impacts of cytochrome P450 3A look for paediatric pharmacological medicine. Drug Discov. Today 11, 440-445 De Wildt, S.N. et Al. ( 2002 ) Pharmacokinetics and metamorphosis of unwritten Versed in preterm babies. Br. J. clin. Pharmacol. 53, 390-392 Patki, K.C. ( 2004 ) Consequence of age on in vitro triazolam biotransformation in male human liver microsomes. J. pharmocol. Exp. Ther. 308, 874-879 Strolin Benedetti, M. et Al. ( 1992 ) Developmental facets of the monoamine-degrading enzymes monoamine oxidases. Dev. Pharmacol. Ther. 18, 191-200 Kornhuber, J. et Al. ( 1989 ) Growth of monoamine oxidase-A and -B in the human encephalon frontal cerebral mantle. Brain Res. 499, 81 Karg, E.et Al. ( 2001 ) Ferroxidases and xanthine oxidoreductase in plasma of healthy newborn babies. Free Radic. Res. 35, 555-561 Tayama, Y. et Al. ( 2007 ) Developmental alterations of aldehyde oxidase activity in immature Nipponese kids. Clin. Pharmacol. Ther. 81, 567-572 Eskura, I. et Al. ( 2006 ) Xanthine oxidase does non lend to impaired peripheral conduit arteria endothelium-dependent distension with ageing. J. Physiol. 571, 661-668 Ecobichon, D.J. and Stephens, D.S. ( 1971 ) Perinatal development of blood exterases. Clin. Pharmacol. Ther. 14, 41-47 Morselli, P.L. et Al. ( 1980 ) Clinical pharmacokinetics in neonates and babies. Clin. Pharmacokin. 5, 485-527 Puche, E. et Al. ( 1989 ) Serum aspirin-esterase activity in epileptic patients having intervention with Phenobarbital, diphenylhydantoin, carbamazepine and valproic acid. Int. J. Clin. Pharm. Res. IX, 55-58 Pope, C.N. et Al. ( 2005 ) Comparative carboxylesterase activities in babies and grownup liver and their in vitro sensitiveness to chlorpyrifos oxon.Regul. Toxicol. Pharmacol. 42, 64-69 Abou Hatab, K. et Al. ( 2001 ) Relationship between age and plasma esterases. Age Aging 30, 41-45 Alam, S.M. et Al. ( 1977 ) Age related differences in salicylamide and acetaminophen junction in adult male. J. pediatr. 90, 130-135 Court, M.H. et Al. ( 2001 ) Interindividual variableness in acetaminophen glucuronidation by human liver microsomes: designation of relevant acetaminophen UDP-glucuronosyltransferase isoforms. J. pharmacol. Exp. Ther. 299, 998-1006 Strassburg, C.P. et Al. ( 2002 ) Developmental facets of human hepatic drug glucuronidation in immature kids and grownups. Gut 50, 259- 265 Temellini, A. et Al. ( 1991 ) Interindividual variableness in the glucuronidation and sulphation of ethinyloestradiol in human liver. Br. J. clin. Pharmacol. 31, 661-664 Tateishi, T. et Al. ( 1995 ) Influence of aging on the oxidative and conjugative metamorphosis of propranolol. Int. J. Clin. Pharmacol. Res. 5, 95-101 Miners, J.O. et Al. ( 1988 ) Comparison of paracetamol metamorphosis in immature grownup and aged males. Eur. J. Clin. Pharmacol. 35, 157-160 Wynne, H. et Al. ( 1990 ) The association of age and infirmity with paracetamol junction in adult male. Age Aging 19, 419-424 Sonne, J.et Al ( 1991 ) Single dosage pharmacokinetics and pharmacodynamics of unwritten Serax in really aged institutionalised topics. Br. J. Clin. Pharmacol. 31, 719-722 Hermann, R. et Al. ( 2003 ) Effects of age and sex on t6he temperament of retigabine. Clin. Pharmacol. Ther. 73, 61-70 Aksoy, I.A. et Al. ( 1993 ) Human liver dehydroepiandrosterone sulfotransferase: nature and extent of single fluctuation. Clin. Pharmacol. Ther. 54, 498-506 Temellini, A. et Al. ( 1993 ) Junction of benzoic acid with glycine in human liver and kidney: a survey on the interindividual variableness. Xenobiotica 23, 1427-1433 McCarver, D.G. and Hines, R.N. ( 2002 ) The growth of human drug metabolising enzymes: stage II junction enzymes and regulative mechanisms. J. pharmacol. Exp. Ther. 300, 361-366 Hoensch, H.et Al. ( 2006 ) Expression of glutathione enzymes system of human colon mucous membrane by localisation, gender and age. Curr. Med. Res. Opin. 22, 1075-1083 Ganiere-Monteli, C. et Al. ( 2004 ) phenotype and genotype for thiopurine methyltransferase activity in the Gallic Caucasic population: impact of age. Eur. J. Clin. Pharmacol. 60, 89-96 Johnson, T.N.et Al. ( 2006 ) Prediction of the clearance of 11 drugs and associated variableness in newborns, babies and kids. Clin. Pharmacokin. 45, 931-956 Strolin Benedetti, M. et Al. ( 2006 ) Engagement of enzymes other than CYPs in the oxidative metamorphosis of xenobiotics. Expert Opin. Drug Metab. Toxicol. 2, 895-921 Olive, G. ( 1991 ) Pharmacocinetique et biotransformation diethylstilbestrols medicines chez lenfant. Louvain Med. 110, 565-569 Oesterheld, J.R. ( 1998 ) A reappraisal of development facets of cytochrome P450. J. Child Adolescent Psychopharmacol. 8, 161-174 Kalow, W. and Tang, B.K. 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Macroenvironment Challenges Of Swatch Group Essay Example

Macroenvironment Challenges Of Swatch Group Essay Example Macroenvironment Challenges Of Swatch Group Paper Macroenvironment Challenges Of Swatch Group Paper Contemporary organizations face changes everyday, including structural change and management change (Bestial Jargon 2014). Gerber (2013) discussed that change in the workplace is unavoidable and it should be embraced by the managers to ensure the transition process is smooth. The change is sometimes attributed to the general environment which defined as a relatively distant environment and it consists of elements such as technological and demographic that influent an organization indirectly (Laureate Florin, 2012). Since the environmental forces impact the organization significantly, the structural and technical change cannot be obtained with closed system (Danish, Minor, Karakas, Jabber Unwary, 2014). Along With the changes of general environment, managers roles have been changed. According to Integer (1 975), managers roles can be distinguished into ten basic roles which mainly classified under interpersonal, informational and decision roles (SICKLINESS, 2007). Since there will be constant changes in the general environment, the managers should be able to perform more roles and being more flexible (Pence, 2001 cited in ICELINKS, 2007). Swatch Group Ltd is a worldwide organization active in watching industry. It consists of 18 well-known watch brands such as Omega and Swatch and nearly all the watch components required by the brands supplied by the Group (Lorena, 2014). Besides, most of the third- party watchmakers of the world demand for its watch movements and components. Its headquartered located in Bill, Switzerland and 33590 employees work for it as of December 31, 2013. The purpose of writing this essay is to analyses the two general environment factors that influent the operation of Swatch Group and to discuss to which extent the work of managers would be impacted. Economic condition and technological notation are the two factors that will be discussed and the theories that will be applied are Henry Payolas Management Functions which consists of planning, organizing, controlling and leading, Roberto L. Stats Management Skills which are conceptual skills, human skills and technical skills, Payolas General Administrative Theory which consists of 14 points, as well as Henry Integers Management Roles . As Swatch Group is globalizes, it has to work with the complex and dynamic global business environment, in other terms, open system under systems approach (Anthrax Inkers, 2013). Economic condition is one of the general environments that affects the operation of the Group, for example, fluctuation of currency exchange. Since it operates its business over the globe, revenues repatriated from overseas have to convert to Swiss Franc currency. Therefore, the groups profit could be negatively affected by fluctuations of currencies against Swiss Franc like the US Dollar and the China Rene Min Bi (The Swatch Group Ltd SOOT Analysis, 2014). Throughout the first half year of 2014, 188 million Francs are shaved from the Groups gross sales because of the extremely adverse exchange rate situation (Lorena, 2014). By comparing the annual financial report of 2007 to 2014 of the Group, the gross sales increase consistently but the currency exchange rate of Swiss Francs display a very unstable rate, especially in 2011 that has an -10. 8% exchange rate. Furthermore, the group also concerns about economic recession. When there is economic recession, peoples confidence level will be lower since they have less purchasing power (Abraham, Greenness Mould, 1998). According to The Conference Board (2014) and Housing Industry Association Ltd (2014), most of the countries has achieved a peak consumer confidence level (ICP) in the year 2007 but has clines significantly since that. When people purchase less, apparently the revenue that Swatch Group can generate is lesser. Moreover, metals and plastics, as the main raw materials of a watch, are having a extremely high market prices in recent years and which ultimately leading to a high production cost and low margin of profit for Swatch Group especially Swatch since it uses plastic as the straps of watches (Essays, 2013). Conversely, when the economy is good, peoples spending on luxury range of watches will increase. For example, the gross sales of the Group have a dramatic increase n 2012 and 2013 since the ICP has recovered (Cowcatchers. Com, 2014). To raise awareness of the fluctuation of currency, top line managers of the Group performed resource locator roles by approving a significant decision which required the production line to create a plastic watch featuring with sass bank note to all the pressure groups, mainly the stakeholders (Revile, 2014). Meanwhile, the Chief Executive Officer (CEO), Nick Hayes showed his figurehead and spokesperson roles by suggesting that Swiss National Banks governing bank should carry out some actions to strengthen their currency Revile, 2014). During economic recession, top line managers of Swatch Group have engaged in planning by setting the strategy of concentrating on lower-end. Since the consumers will more tempted to buy products that are relatively low in price, the decision of differentiating and dividing products with a pricing strategy is made. For example, basic range like Swatch and luxury range like Omega. Different brands target on different classes by ingratiating their favor and setting an affordable price. They also engage in organizing which including market surveys that need to be constructed in order to analyses which age group they should target on and what is their common preferences. Middle line managers on the other hand should convey the accurate message of the board to the first-line managers so that they can manage the manufacturing process and the retail sales. The sales during the economic downturn period can also be stimulated by further increasing the visibility of the brands. One of the actions that the Group has taken is that they have sponsored plenty of sporting events. For instance, top line managers of the headquarters played the role of spokesperson and figurehead by signing agreement with International Olympic Committee to become Olympic Partners sponsor and official timekeeper of the game (Themselves, 2002). On the other hand, the marketing managers, as the middle line managers control and manage the details of the events. Human skills are very important for them as the corporation with other departments and the Committee are unavoidable. They should able to communicate, lead and inspire enthusiasm. Meanwhile, to ensure that the timers are functioned properly, technical skills are inevitable and the first-line mangers have to respond to any situation changes, which comply with situational approach (Magmata Susquehanna, 2009). Secondly, technological condition also influent the Groups operation. Swatch Group is challenged by schismatic, which is highly focused when Pebble launched its kick-starter campaign in 2012 (Destroyers, 2013). Although the weaknesses of smart watch like highly dependent on smartened have not been overcame, Samsung Galaxy Gear watch has dominated 78 percent of 96 million revenue gained in schismatic market of US (Roar, 2014). This promising sales figures may be a threat for Swatch Group in a long run, especially when the schismatic passes the chasm of technology by having a better functionality. Based on a market research that took a sample size of 2577 adults in US, 63% of echo boomers, who are those who aged between 18 to 35 years old has slightly interested in owning a schismatic (Shannon- Missal, 2013). Besides, since the counterfeit watches are much cheaper and kick alike as the original watch, they occupy a huge market share. What make the situation worse is the people who wants to buy original but unintentionally buy a counterfeit watch. In a long run, peoples loyalty towards the branded products will loss and brands reputations will be damaged. In response to the new era, top line managers of the Group perform their inception skills as they made a decision to corporate with Microsoft in laughing a schismatic called Paparazzi ten years ago. Although the schismatic did not bring the expected succeed, both Research and Development departments showed their proficiency in technical skills. Moreover, the PR and marketing managers are the bridge to connect both organizations and hence human skills which used to build cooperative effort become extremely important. Meanwhile, Hayes does not agree with the says that schismatic is a threat to them, instead, he is very confident that it is a hence for them to convince people who willing to wear a schismatic try on their products (Kilowatt Potter, 2014). He did played his job well in the aspect of representing the Groups information and thought to the media, whether in another term, spokesperson. Moreover, as a leader, he has motivated and gave a clear direction to the employees during the time when the employees are worried about the future of the company due to the presence of schismatic. Although the technology advance has brought many challenges to Swatch Group, it can also treated as an opportunity. Since there are people who enjoy online-shopping nowadays, a new platform, e-commerce have been introduced to reduce the chance loss. The main jobs of e-commerce developers are to ensure that the e-business of the group are operated smoothly, the users and technical documents are established, which perfectly interpret the responsibilities of first-line manager, thus the proficiency in relative technical skills is strongly required (Swatch Group, 2014). The corporation of many departments including marketing department and IT department are required since the head of the departments, also known as middle line managers have to manage what products can be sold via the web hill the first-line manager, mainly the technicians and the salesperson have to ensure the website is updated, operated normally and the proper manner used when communicate with consumers. The top line managers like the CEO have to keep track on the online sales. Furthermore, to ensure that the employees are aware of the worlds change, the Group gives training on technical-know-how, interpersonal skills and acquisition of competencies to their employees (Cowcatchers. Com, 2014). The team leader, no matter which line of managers should show their leader role by understanding what the employees request for and are they being motivated enough. This in turn aids in promoting the esprit De corps principle that builds harmony and a united front within the organization, according to Payolas 1 4 principles (Wren Bedside, 2009). In conclusion, economic and technological are two of the general environments that affect the Groups operation in positive and negative ways. The changes are unavoidable but the ways that the managers embrace and adapt to it determine the smoothness of its operation. Therefore, managers, which are human capital of Swatch Group is one of its key success factors as they dedicates great effort to the Group according to the positions they hold ND the responsibilities they carry.

Free Essays on Passion Of The Christ Reaction

The extent of the accuracy of the film was unbelievable. To have the entire movie’s dialogue be in Aramaic was the most incredible thing. Before watching the film I though that Mel Gibson might massacre the story by exaggerating or falsifying aspects of it but he truly did stick to the historic Biblical version. The only thing that wasn’t exactly known to be true is the idea of Lucifer appearing to Jesus throughout his ordeal but I would find it very possible that Lucifer be there watching Jesus suffer. The definition of anti-Semitism is hostility toward or discrimination against Jews as a religious, ethnic, or racial group. Does this film lead me to these feelings? In most ways, no. But being a Christian watching the Jewish high priests and crowds of Jewish people sentencing Jesus to his horrible death, I did experience hatred towards those people. Do I feel like the Jewish community of today is in anyway responsible for what happened? No. And so, I would argue that you had to have entered the film with feelings of Anti- Semitism to be able to have exited with those feelings. I felt that as far as the issue of the goriness of the film, I understand why Mel Gibson felt it was necessary. As far as accuracy goes, that is the way we as Christians believe it played out. This was a way for society to view what Jesus went through for us, to what excruciating pain he suffered for our sins. How or where else would there be a better venue then through this film for us all to see the torture and be a little bit humbled about our own petty complaints. In many ways I felt like he took it a bit far to the point that I didn’t want to watch but then I realized if he suffered that much couldn’t I discomfort myself slightly and watch it? My personal reaction towards the film was positive and overwhelming. It was really strange to see the story come to life on film. I felt a little depressed afterwards. I felt that the actor who played Jesu... Free Essays on Passion Of The Christ Reaction Free Essays on Passion Of The Christ Reaction The extent of the accuracy of the film was unbelievable. To have the entire movie’s dialogue be in Aramaic was the most incredible thing. Before watching the film I though that Mel Gibson might massacre the story by exaggerating or falsifying aspects of it but he truly did stick to the historic Biblical version. The only thing that wasn’t exactly known to be true is the idea of Lucifer appearing to Jesus throughout his ordeal but I would find it very possible that Lucifer be there watching Jesus suffer. The definition of anti-Semitism is hostility toward or discrimination against Jews as a religious, ethnic, or racial group. Does this film lead me to these feelings? In most ways, no. But being a Christian watching the Jewish high priests and crowds of Jewish people sentencing Jesus to his horrible death, I did experience hatred towards those people. Do I feel like the Jewish community of today is in anyway responsible for what happened? No. And so, I would argue that you had to have entered the film with feelings of Anti- Semitism to be able to have exited with those feelings. I felt that as far as the issue of the goriness of the film, I understand why Mel Gibson felt it was necessary. As far as accuracy goes, that is the way we as Christians believe it played out. This was a way for society to view what Jesus went through for us, to what excruciating pain he suffered for our sins. How or where else would there be a better venue then through this film for us all to see the torture and be a little bit humbled about our own petty complaints. In many ways I felt like he took it a bit far to the point that I didn’t want to watch but then I realized if he suffered that much couldn’t I discomfort myself slightly and watch it? My personal reaction towards the film was positive and overwhelming. It was really strange to see the story come to life on film. I felt a little depressed afterwards. I felt that the actor who played Jesu...

Module 6 DQ1 and 2 Article Example | Topics and Well Written Essays - 500 words

Module 6 DQ1 and 2 - Article Example Such things as antivirus software and password or smart card logons help facilitate this. Data redundancy is backing up necessary computerized information so that it is available elsewhere in the event of a disaster. Most use what is known as a COOP site, an offsite storage area that is reasonably safe from fire, flood, and a myriad of other problems. Because mechanical items fail, data redundancy also can refer to having extra servers and computer equipment available so that the facility can continue to operate (IAHSS 2012). After the devastating effects on healthcare caused by Hurricanes Sandy and Katrina, those administrators would probably agree with this author that redundancy is the most important of the three areas discussed in this paper. HIPAA 1996 and its successor, PPACA 2009 (Obama Care) do tend to place what appears to be a rather large burden on healthcare providers concerning privacy (HHS 2013). However, as described above, the laws as written attempt to help keep providers and patients alike comfortable in the knowledge that necessary personal information (such as social security numbers) is not released to the public, as was the case with the VA employee who lost thousands of SSN’s. The Health Insurance Portability and Accountability Act (HIPAA) provides a list of what it refers to as "identifiable patient information†. Although the law allows the use of the information for clinical use, the Act entails strict privacy rules that must be adhered to (HHS 2013). It specifically disallows release of such information, except in those particular circumstances as outlined. This includes what HIPAA refers to as â€Å"demographic† information as that is defined as those statistics or characteristics that define a certain segment of the population. Such items as name, address, Social Security Number, and date of birth are specified, as well as

Discussions Assignment Example | Topics and Well Written Essays - 1250 words

Discussions - Assignment Example On the contrary, those with little or no self-efficacy have no control of tempting and hard situation and will hence succumb to activities such as irresponsible sexual activity and unnecessary drug use. The big question that arises is â€Å"can people with low self-efficacy be helped to improve on the same?† the answer is a big reassuring yes. Through health education programs to people especially adolescents can be helped to adequately improve their self efficacy. But exactly how can this be achieved? It is very simple; the adolescents through the health educator programs are taught to always consider the long term effects of their actions rather than just the tempting pleasurable impact of the situation at hand. In the process the adolescents are taught to always weigh immediate tempting pleasurable effects of the situation and the future devastating effects. If the future effects outweigh the effects presented in that moment in terms of risk then the adolescents should avoi d the situation but if the future benefits outweigh the present risk then they should cautiously consider other factors then undertake the activity if no other risks are involved (Bastani 67). In short the adolescent are cautioned to always think out of the box when faced with such a situation. For example through ‘one on one dialogues’ and ‘abstain from sex’ campaigns adolescents can be made aware of the impact of irresponsible sexual activities. The adolescents can be educated on the benefits of abstaining and refraining from irresponsible sex amongst themselves. Safe sexual activities such as abstaining and use of condoms can also be instilled in such adolescents in the process. Adolescents who have undergone the educator program will easily avoid irresponsible sex than those who haven’t simply because they will have the knowledge of what they are getting into (Karimzadeh 105). Number 2 Brief interventions in substance use treatment. This was the title of an article posted on www.ncbi.nlm.nih.gov/booksNBK64942/. The article is generally about the model used by professionals such as psychologists, nurses, social workers among others to individuals who can’t access special care or those who simply don’t want to access it. One of the brief interventions mentioned is the stages of change model. The stages of change model were credited with the success of helping smokers quit the vice. Support that involves a huge deal of motivation directed to the person who wants to deal with the substance abuse problem is vital for the model to prove successful. The first stage that was identified is where the individual gives excuses. Afterwards a new phase is arrived at where the individual admits that the drug use indeed is a problem to him or her, but he or she is not ready to quit the vice. Later, the individual enters a new phase where the individual has given a thought of trying to quit and is now preparing to do so. The n ext stage is the most important it is referred to as the action stage because it is the stage where the individual now put his or her words and intentions into action by literally halting the consumption of the drug. It mostly happens four weeks after contemplation of stopping the vice but it might sometimes even take six months. In this stage the individual should receive ample and regularly support to help cope with the withdrawal symptoms. After the action stage the individ

Nursing in a Day Surgery Essay Example | Topics and Well Written Essays - 1500 words

Nursing in a Day Surgery - Essay Example In order to do this the discussion will first of define pain, because it not objective as many nurses and health practioners may believe. In fact it is a very subjective term. The discussion will end by considering the problems in the UK when dealing with patient's whose wishes are hard to discern and whether we should be administering pain relief methods without proper consent. It is this balance between whether nurses, as myself, should be acting on the wishes of the doctors and the establishment or the patient's wishes and concerns. This is because speed and cost efficiency should not be a determining factor in a patient's health, rather if a person who has varicose vein surgery is more suited for overnight care this should be considered. Pain was found to be the major concern for patients undergoing surgery and they wanted access to information both verbally and through written communication (Taylor. H. 2001). Patients have evinced interest in knowing the details of their recovery and realistic accounts of discomfort that they can expect. Addressing the cognitive component of pain is easily done through patient education (Carr C.J. Ellois. 2001). An audit at the Warwick Hospital found that although patient education booklets were available, the APS refrained from giving out this information. Besides, patients were not consulted in the development of the services Patients usually felt better and less ... Many used past experiences as reference for their expectations. Some studies found that patients had lower expectations of post-surgical pain. Patients also had a number of misconception related to the use of analgesia. This led to under usage of drugs and poor pain management. Understanding these factors can help nurses develop educational manuals for patients and help in better pain management (Taylor). H. 2001). The NIH has given Guidelines for the preparation of patient education and state the all communication must be, "clear, cost-effective, straightforward, modern, accessible, honest and respectful."(DoH, 2001) The Royal College and the Anaesthetic Association reported that 44% of hospitals had some form acute care services and 79% used modern analgesic techniques to manage pain (Carr C.J. Ellois. 2001.) A study of hospital services declares pain prevention to be one of the 10 most important indicators of care quality. (Susan M, 2003) While the need for management is acknowledged, the resources allocated for the function were found to be inadequate. In a significant finding, the Clinical Standards Advisory Group found that although 81% of the functions involve nursing care and 7% of these were headed by nurses there was lack of specialized nursing care in the chronic pain department. The situation was further made worse by inadequate funding. (Pain Society, 2001) Health professionals currently are found to have deficits in knowledge and skills for proper pain management. Nursing care is often found to be influenced by attitude of patients, their culture and value systems. (Redorbit.com, 2006) . The Services for Patients with Pain, in

Cognitive Problems of Bilingual Speakers Essay Example | Topics and Well Written Essays - 750 words

Cognitive Problems of Bilingual Speakers - Essay Example Aphasic in bilinguals is a complex problem influenced by internal and external factors such as localization, "switch" interaction, suppression of a native language and a specific role of the right hemisphere of the brain. Questions specific to bilingual aphasia are added to those stemming from aphasia in general, such as whether aphasia is a general cognitive deficit or a language-specific impairment; whether it is a unitary phenomenon or admits of multiple syndromes; whether it is a deficit of competence or performance; and whether modality-specific deficits are aphasic symptoms. Theoretical positions on these issues will have consequences for hypotheses about bilingual aphasia and/or the representation of two languages in one brain. Some authors, for example, argue that patients are not aphasic unless their competence is impaired. Competence is considered not to be impaired when a deficit is not equally manifested in all modalities or when a patient undergoes spontaneous recovery. Moreover, because it is assumed that competence is common to both languages, if a bilingual is agrammatic for some aspect of the grammar in one of his languages, it is predicted that she or he will be agrammatic for those same components of the grammar in the other language ( Scholes, 1984). Thus, what recovers spontaneously in unilinguals and bilinguals as well as what is differentially deficient in bilinguals is not considered a result of impaired competence but of loss of access through some defective performance mechanism. Such a position therefore holds that any bilingual patient exhibiting nonparallel recovery is not aphasic. The unstated assumption behind the argument is the role of primary education and background of a person. Whether or not teachers call students aphasic who have lost the use of one of their languages or who have differential postmorbid proficiency in each language, it is of interest to the neuropsychology of language in general and of bilingualism in parti cular to examine whether nonparallel deficits do indeed occur, and if so, to investigate the mechanisms responsible for differential, successive, selective, antagonistic, and mixed recoveries. The article is well-structured and is based on substantial research and data analysis. A researcher gives a special attention to the systemic-dynamic approach and their age, proficiency and motivation among students. The researcher uses inductive reasoning using specific examples and data. The arguments and claims are well-supported and explained. The researcher underlines that there is no a priori reason to reject the possibility that each language might be subserved by its own competence, namely, that each grammar might be separately stored and/or processed. There is indeed no clinical evidence that there is only one underlying neurolinguistic competence for both languages, that is to say, one common neural substrate for language, undifferentiated as to specific language. If it can be shown that specific alterations in competence occur in one language and not in the other, then it is not unreasonable to assume that each language is subserved by different neurofunctional substrates. Further systematic investigations, based on large numbers of successive unselected cases and

Why did God become man in Jesus Christ Essay Example | Topics and Well Written Essays - 2000 words

Why did God become man in Jesus Christ - Essay Example How the death of Jesus Christ, as a man, could become an act of redemption for all human beings is further explained by St. Athanasius. It is revealed that â€Å"in His death all might die, and the law of death thereby be abolished because, having fulfilled in His body that for which it was appointed, it was thereafter voided of its power for men.† And this became the completion of a circle that started when man was banished from the Garden of Eden with the cure of death fallen upon him. And this is why as Corinthians 15:22 says, â€Å"in Adam, all die† but in Jesus, all resurrect. Such an intervention by God became imperative just because man had once â€Å"shared the nature of the Word† but the same man was now the slave of corruption, made so by the â€Å"deceit† of the devil. As the second coming of Jesus as indicated in the Messianic prophesy, is to impart the â€Å"final death blow† to Satan, this second coming in all possibilities will not be in the form of man again. The Revelation 001:007 of the Bible has made a record of this second coming and has said, â€Å"behold, he is coming with the clouds, and every eye will see him, including those who pierced him.† From the allusion to the clouds, it is clear that Jesus is not coming the second time as a man, a mortal. Hence it has to be concluded that only the first coming of Jesus is the first and last instance in which he is coming as a mortal. This is the real rarity of the situation.

Marketing coursework Example | Topics and Well Written Essays - 3000 words

Marketing - Coursework Example Agriculture and any other economic activity such as tourism cannot thrive in a society that does not have efficient water management strategies. Challenges related to water in Ethiopia have persisted for several decades now. Management of water resources is the only way to meet the growing needs for agricultural products soas to help reduce poverty and food insecurity. Further, water can be used as an important entry point to bring development in the social environment and economy thus leading to sustainable development (Gabre-Egziabher 2007, p.67). Ethiopia is also challenged with several civil wars. Ethnic communities have been fighting each other over the scarce resources in the country. The civil wars have also been linked to poor governance because there are numerous corruption scandals affecting the delivery of services to all ethnic communities. As a result, wars between communities have emerged. This level of insecurity cannot allow the smooth flow of tourists in the country (Kiros 2006, p.212). Due to mismanagement of water resources, Ethiopia has witnessed one of the worst droughts in the world. Human beings have died due to famine which prompted the international community to intervene and save the citizens from the great famine of Ethiopia that occured in 1986. Drought cannot allow any agricultural activity to take place, which is why food prices continue to be highin the country . According to the United Nations, Ethiopia is one of the countries that depend on relief food for its population’s survival (Brems & Beken 2008, p.129). Any investment in the tourism sector needs adequate infrastructure such as good road and railway systems. In Ethiopia, there are no adequate roads that can easen the movement of tourists from one region to another. The road networks as well as the rail systems are underdeveloped. The movement of tourists from one place to another cannot be easy in such a situation. In addition, there are no adequate airports that ca n provide air transport to various tourist attraction sites in the country (Asfaw 2006, p.48). In relation to security, Ethiopia does not have the right security personnel equipped with modern technology to identify terror threats. Terrorism continues to be one of the challenges affecting tourism. Without guaranteed security, there can never be any benefit arising out of the industry. In addition, the numerous ethnic conflicts are also not suitable for tourist visits to the attraction sites (Asfaw 2006, p.48). The weak and developing justice system does not provide procedural guarantees including legal aid, an appeal system, fair trial and equity before law. Despite these issues being given priority in the constitution, their implementation is still a challenge. The unreliable justice system is not friendly to potential investors in the country. Furthermore there is a severe shortage of trained legal staff meaning that potential investors and players in the tourism sector lack confi dence in the delivery of justice (Gabre-Egziabher 2007, p.67). Political repression is a major challenge to the citizens of Ethiopia. The ruling party EPRDF has continued to trample on the rights of the citizens. Opposition leaders are not given a chance to air their grievances concerning the illegal dealings and scandals in the government. The government has punitive legislative laws aimed at the press and the civil society. The main aim of the government is to affect the

Cognitive Problems of Bilingual Speakers Essay Example | Topics and Well Written Essays - 750 words

Cognitive Problems of Bilingual Speakers - Essay Example Aphasic in bilinguals is a complex problem influenced by internal and external factors such as localization, "switch" interaction, suppression of a native language and a specific role of the right hemisphere of the brain. Questions specific to bilingual aphasia are added to those stemming from aphasia in general, such as whether aphasia is a general cognitive deficit or a language-specific impairment; whether it is a unitary phenomenon or admits of multiple syndromes; whether it is a deficit of competence or performance; and whether modality-specific deficits are aphasic symptoms. Theoretical positions on these issues will have consequences for hypotheses about bilingual aphasia and/or the representation of two languages in one brain. Some authors, for example, argue that patients are not aphasic unless their competence is impaired. Competence is considered not to be impaired when a deficit is not equally manifested in all modalities or when a patient undergoes spontaneous recovery. Moreover, because it is assumed that competence is common to both languages, if a bilingual is agrammatic for some aspect of the grammar in one of his languages, it is predicted that she or he will be agrammatic for those same components of the grammar in the other language ( Scholes, 1984). Thus, what recovers spontaneously in unilinguals and bilinguals as well as what is differentially deficient in bilinguals is not considered a result of impaired competence but of loss of access through some defective performance mechanism. Such a position therefore holds that any bilingual patient exhibiting nonparallel recovery is not aphasic. The unstated assumption behind the argument is the role of primary education and background of a person. Whether or not teachers call students aphasic who have lost the use of one of their languages or who have differential postmorbid proficiency in each language, it is of interest to the neuropsychology of language in general and of bilingualism in parti cular to examine whether nonparallel deficits do indeed occur, and if so, to investigate the mechanisms responsible for differential, successive, selective, antagonistic, and mixed recoveries. The article is well-structured and is based on substantial research and data analysis. A researcher gives a special attention to the systemic-dynamic approach and their age, proficiency and motivation among students. The researcher uses inductive reasoning using specific examples and data. The arguments and claims are well-supported and explained. The researcher underlines that there is no a priori reason to reject the possibility that each language might be subserved by its own competence, namely, that each grammar might be separately stored and/or processed. There is indeed no clinical evidence that there is only one underlying neurolinguistic competence for both languages, that is to say, one common neural substrate for language, undifferentiated as to specific language. If it can be shown that specific alterations in competence occur in one language and not in the other, then it is not unreasonable to assume that each language is subserved by different neurofunctional substrates. Further systematic investigations, based on large numbers of successive unselected cases and